Yes, and not only according to the data on the Epson website ;-)

The best printer ever. The large ink tanks work perfectly, it can also print A3 and iEpson lets me print from the Sosa. I don't know the other devices

I don't know the ET-1600 and therefore don't know the difference. But my ET-16650 can print A3.
I'm also happy with the printer.

... and he uses pigmented colours. That was the reason I bought it. I am very satisfied with the ET-16650.