Robert Langdon, a Harvard symbologist, accompanies his girlfriend Katherine Solomon to Prague. Katherine is preparing to publish a book that reveals groundbreaking discoveries about the true nature of human consciousness. However, a brutal murder plunges the trip into unpredictable chaos, and Katherine suddenly disappears, along with her manuscript. Langdon finds himself up against a powerful organization and is pursued by a sinister attacker who seems to have emerged from Prague's oldest mythology, driven by a single goal: relentless revenge.