More than a century after the bombs fell, Arizona is dying. The Patriarch of Colorado has promised to save it if the Desert Rangers can free his land from his three bloodthirsty children. In this tactical RPG, the Rangers must travel north to establish a new base, equip a vehicle, train recruits, explore Colorado's hostile, frozen wasteland, meet the locals, and decide whom to help.

In Wasteland 3, Colorado's fate determines Arizona's fate. You are a Desert Ranger fighting an almost hopeless battle to keep your beloved Arizona alive when the self-proclaimed Patriarch of Colorado promises assistance if you complete a task he can only entrust to an outsider – save his land from the ambitions of his three bloodthirsty children.

So you travel from the scorching desert to the frozen mountains and start from scratch. You build a new base, find a snow-worthy vehicle, train new recruits, and fight your way through the hostile wilderness while trying to decide whom to trust in a land torn apart by corruption, intrigue, warring factions, fanatical cultists, murderous gangs, and bitter sibling rivalry. You're not even sure you can trust the Patriarch, but he ultimately holds Arizona's survival in his hands. Can you afford not to?.