Yes, several monitors can be operated. Provided there are enough free connections on the PC (or Mac) and the graphics card is sufficiently powerful. This is actually no problem with modern computers. By the way, the monitor can also be operated on an Apple computer without any problems. You should also be aware that the Samsung Space Monitor has ONLY one HDMI connection. Although there is a USB port, this is only used for firmware updates and support. So you still need the corresponding adapters (e.g. from USB C to HDMI) to connect the monitor to the computer.
In general, the monitor is really a dream and highly recommended for normal everyday use!
Not suitable for gamers!
However, the monitor holder is bad! It is elegant, but does not allow enough freedom of movement (e.g. rotation in the vertical axis is not possible). This was not acceptable to me. I made myself an adapter, replaced the original monitor holder and now use a universal monitor holder. This works very well! If you have any questions, please do not hesitate to contact me.
In any case, the monitor is worth it! Greetings