The Logitech Unifying receiver is compatible with all Logitech Unifying products that support Unifying technology. To ensure that the Logitech mk295 Silent Combo is compatible with a Unifying receiver, you should check whether the set uses Unifying technology. If not, you will need a receiver that is specifically designed for the mk295 Silent Combo. The Logitech mk295 Silent Combo normally uses a Nano receiver, which is not compatible with Unifying technology.