The monitor is generally compatible with the Mac Mini 4, as it offers standard connections such as HDMI, DisplayPort and USB-C, which the Mac Mini supports. However, there are reports that the Dell P2425H is not officially supported by macOS and that certain applications (e.g. Dell Display Manager) may experience problems such as not recognising the monitor.

In general, the monitor works well with macOS, especially for office applications, and window behaviour is stable. However, there may be limitations when displaying text documents or using special macOS functions, as the monitor is not on the macOS support list and no macOS-specific drivers (DDPM) are provided.

So if you value full macOS compatibility and optimal graphics display, there may be limitations. However, the monitor is suitable for simple office applications and standard use.