The Logitech Unifying receiver is not directly compatible with the Logitech MK270 Combo, as it normally uses a nano receiver that is not compatible with Unifying technology. To use the MK270 Combo, you need the specific Nano receiver that comes with the set. However, the Unifying receiver is compatible with all Logitech products that support Unifying technology, such as the K750 Solar Keyboard.