Robert Langdon, a symbol researcher from Harvard, accompanies his girlfriend Katherine Solomon to Prague. Katherine is preparing to publish a book that reveals groundbreaking discoveries about the true nature of human consciousness. However, a brutal murder throws the trip into unpredictable chaos, and Katherine suddenly disappears, along with her manuscript. Langdon finds himself facing a powerful organization and is pursued by a sinister attacker who seems to have emerged from Prague's oldest mythology, with a single goal: merciless revenge.